Internalization of the chemokine receptor CCR4 can be evoked by orthosteric and allosteric receptor antagonists

The chemokine receptor CCR4 has at least two natural agonist ligands, MDC (CCL22) and TARC (CCL17) which bind to the same orthosteric site with a similar affinity. Both ligands are known to evoke chemotaxis of CCR4-bearing T cells and also elicit CCR4 receptor internalization. A series of small mole...

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Detalhes bibliográficos
Main Authors: Ajram, Laura, Begg, Malcolm, Slack, Robert, Cryan, Jenni, Hall, David, Hodgson, Simon, Ford, Alison, Barnes, Ashley, Swieboda, Dawid, Mousnier, Aurelie, Solari, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2014
Assuntos:
Immunopharmacology and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989064/
https://ncbi.nlm.nih.gov/pubmed/24534492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2014.02.007
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