Internalization of the chemokine receptor CCR4 can be evoked by orthosteric and allosteric receptor antagonists

The chemokine receptor CCR4 has at least two natural agonist ligands, MDC (CCL22) and TARC (CCL17) which bind to the same orthosteric site with a similar affinity. Both ligands are known to evoke chemotaxis of CCR4-bearing T cells and also elicit CCR4 receptor internalization. A series of small mole...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ajram, Laura, Begg, Malcolm, Slack, Robert, Cryan, Jenni, Hall, David, Hodgson, Simon, Ford, Alison, Barnes, Ashley, Swieboda, Dawid, Mousnier, Aurelie, Solari, Roberto
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier Science 2014
Pynciau:
Immunopharmacology and Inflammation
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989064/
https://ncbi.nlm.nih.gov/pubmed/24534492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2014.02.007
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