Internalization of the chemokine receptor CCR4 can be evoked by orthosteric and allosteric receptor antagonists

The chemokine receptor CCR4 has at least two natural agonist ligands, MDC (CCL22) and TARC (CCL17) which bind to the same orthosteric site with a similar affinity. Both ligands are known to evoke chemotaxis of CCR4-bearing T cells and also elicit CCR4 receptor internalization. A series of small mole...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Ajram, Laura, Begg, Malcolm, Slack, Robert, Cryan, Jenni, Hall, David, Hodgson, Simon, Ford, Alison, Barnes, Ashley, Swieboda, Dawid, Mousnier, Aurelie, Solari, Roberto
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Elsevier Science 2014
Θέματα:
Immunopharmacology and Inflammation
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989064/
https://ncbi.nlm.nih.gov/pubmed/24534492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2014.02.007
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