GPR40 (FFAR1) – Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo

OBJECTIVES: GPR40 (FFAR1), a clinically proven anti-diabetes target, is a Gq-coupled receptor for long chain fatty acids (LCFA) stimulating insulin secretion directly and mediating a major part of the dietary triglyceride-induced secretion of the incretins GLP-1 and GIP. In phase-II studies the GPR4...

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Bibliografske podrobnosti
izdano v:Mol Metab
Main Authors: Hauge, Maria, Vestmar, Marie A., Husted, Anna S., Ekberg, Jeppe P., Wright, Michael J., Di Salvo, Jerry, Weinglass, Adam B., Engelstoft, Maja S., Madsen, Andreas N., Lückmann, Michael, Miller, Michael W., Trujillo, Maria E., Frimurer, Thomas M., Holst, Birgitte, Howard, Andrew D., Schwartz, Thue W.
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2014
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4314522/
https://ncbi.nlm.nih.gov/pubmed/25685685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2014.10.002
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