Gs/Gq signaling switch in β cells defines incretin effectiveness in diabetes

By restoring glucose-regulated insulin secretion, glucagon-like peptide-1–based (GLP-1–based) therapies are becoming increasingly important in diabetes care. Normally, the incretins GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) jointly maintain normal blood glucose levels by stimulati...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Oduori, Okechi S., Murao, Naoya, Shimomura, Kenju, Takahashi, Harumi, Zhang, Quan, Dou, Haiqiang, Sakai, Shihomi, Minami, Kohtaro, Chanclon, Belen, Guida, Claudia, Kothegala, Lakshmi, Tolö, Johan, Maejima, Yuko, Yokoi, Norihide, Minami, Yasuhiro, Miki, Takashi, Rorsman, Patrik, Seino, Susumu
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7685756/
https://ncbi.nlm.nih.gov/pubmed/33196462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI140046
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