Gs/Gq signaling switch in β cells defines incretin effectiveness in diabetes

By restoring glucose-regulated insulin secretion, glucagon-like peptide-1–based (GLP-1–based) therapies are becoming increasingly important in diabetes care. Normally, the incretins GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) jointly maintain normal blood glucose levels by stimulati...

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Bibliografske podrobnosti
izdano v:J Clin Invest
Main Authors: Oduori, Okechi S., Murao, Naoya, Shimomura, Kenju, Takahashi, Harumi, Zhang, Quan, Dou, Haiqiang, Sakai, Shihomi, Minami, Kohtaro, Chanclon, Belen, Guida, Claudia, Kothegala, Lakshmi, Tolö, Johan, Maejima, Yuko, Yokoi, Norihide, Minami, Yasuhiro, Miki, Takashi, Rorsman, Patrik, Seino, Susumu
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2020
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7685756/
https://ncbi.nlm.nih.gov/pubmed/33196462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI140046
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