Gs/Gq signaling switch in β cells defines incretin effectiveness in diabetes

By restoring glucose-regulated insulin secretion, glucagon-like peptide-1–based (GLP-1–based) therapies are becoming increasingly important in diabetes care. Normally, the incretins GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) jointly maintain normal blood glucose levels by stimulati...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Oduori, Okechi S., Murao, Naoya, Shimomura, Kenju, Takahashi, Harumi, Zhang, Quan, Dou, Haiqiang, Sakai, Shihomi, Minami, Kohtaro, Chanclon, Belen, Guida, Claudia, Kothegala, Lakshmi, Tolö, Johan, Maejima, Yuko, Yokoi, Norihide, Minami, Yasuhiro, Miki, Takashi, Rorsman, Patrik, Seino, Susumu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7685756/
https://ncbi.nlm.nih.gov/pubmed/33196462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI140046
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