Essential roles of aspartate aminotransferase 1 and vesicular glutamate transporters in β-cell glutamate signaling for incretin-induced insulin secretion

Incretins (GLP-1 and GIP) potentiate insulin secretion through cAMP signaling in pancreatic β-cells in a glucose-dependent manner. We recently proposed a mechanistic model of incretin-induced insulin secretion (IIIS) that requires two critical processes: 1) generation of cytosolic glutamate through...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Murao, Naoya, Yokoi, Norihide, Honda, Kohei, Han, Guirong, Hayami, Tomohide, Gheni, Ghupurjan, Takahashi, Harumi, Minami, Kohtaro, Seino, Susumu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5665537/
https://ncbi.nlm.nih.gov/pubmed/29091932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0187213
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi