The E92K Melanocortin 1 Receptor Mutant Induces cAMP Production and Arrestin Recruitment but Not ERK Activity Indicating Biased Constitutive Signaling

BACKGROUND: The melanocortin 1 receptor (MC1R) constitutes a key regulator of melanism. Consequently, many naturally-occurring MC1R mutations are associated with a change in color. An example is the Glu-to-Lys substitution found at position II:20/2.60 in the top of transmembrane helix II which has b...

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Hauptverfasser: Benned-Jensen, Tau, Mokrosinski, Jacek, Rosenkilde, Mette M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3172247/
https://ncbi.nlm.nih.gov/pubmed/21931793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024644
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