Genetic and biased agonist-mediated reductions in β-arrestin recruitment prolong cAMP signaling at glucagon family receptors

Receptors for the peptide hormones glucagon-like peptide-1 (GLP-1R), glucose-dependent insulinotropic polypeptide (GIPR), and glucagon (GCGR) are important regulators of insulin secretion and energy metabolism. GLP-1R agonists have been successfully deployed for the treatment of type 2 diabetes, but...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Jones, Ben, McGlone, Emma Rose, Fang, Zijian, Pickford, Phil, Corrêa, Ivan R., Oishi, Atsuro, Jockers, Ralf, Inoue, Asuka, Kumar, Sunil, Görlitz, Frederik, Dunsby, Chris, French, Paul M.W., Rutter, Guy A., Tan, Tricia, Tomas, Alejandra, Bloom, Stephen R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948418/
https://ncbi.nlm.nih.gov/pubmed/33268378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.016334
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