Genetic and biased agonist-mediated reductions in β-arrestin recruitment prolong cAMP signaling at glucagon family receptors

Receptors for the peptide hormones glucagon-like peptide-1 (GLP-1R), glucose-dependent insulinotropic polypeptide (GIPR), and glucagon (GCGR) are important regulators of insulin secretion and energy metabolism. GLP-1R agonists have been successfully deployed for the treatment of type 2 diabetes, but...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Jones, Ben, McGlone, Emma Rose, Fang, Zijian, Pickford, Phil, Corrêa, Ivan R., Oishi, Atsuro, Jockers, Ralf, Inoue, Asuka, Kumar, Sunil, Görlitz, Frederik, Dunsby, Chris, French, Paul M.W., Rutter, Guy A., Tan, Tricia, Tomas, Alejandra, Bloom, Stephen R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948418/
https://ncbi.nlm.nih.gov/pubmed/33268378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.016334
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