The Influence of Peptide Context on Signaling and Trafficking of Glucagon-like Peptide-1 Receptor Biased Agonists

[Image: see text] Signal bias and membrane trafficking have recently emerged as important considerations in the therapeutic targeting of the glucagon-like peptide-1 receptor (GLP-1R) in type 2 diabetes and obesity. In the present study, we have evaluated a peptide series with varying sequence homolo...

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Detalhes bibliográficos
Publicado no:ACS Pharmacol Transl Sci
Main Authors: Fang, Zijian, Chen, Shiqian, Pickford, Philip, Broichhagen, Johannes, Hodson, David J., Corrêa, Ivan R., Kumar, Sunil, Görlitz, Frederik, Dunsby, Chris, French, Paul M. W., Rutter, Guy A., Tan, Tricia, Bloom, Stephen R., Tomas, Alejandra, Jones, Ben
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7155199/
https://ncbi.nlm.nih.gov/pubmed/32296773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.0c00022
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