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Potent Prearranged Positive Allosteric Modulators of the Glucagon‐like Peptide‐1 Receptor

Drugs that allosterically modulate G protein‐coupled receptor (GPCR) activity display higher specificity and may improve disease treatment. However, the rational design of compounds that target the allosteric site is difficult, as conformations required for receptor activation are poorly understood....

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Detalhes bibliográficos
Publicado no:ChemistryOpen
Main Authors: Jones, Ben J., Scopelliti, Rosario, Tomas, Alejandra, Bloom, Stephen R., Hodson, David J., Broichhagen, Johannes
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5542757/
https://ncbi.nlm.nih.gov/pubmed/28794944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.201700062
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