Positive Allosteric Modulation of the Glucagon-like Peptide-1 Receptor by Diverse Electrophiles

Therapeutic intervention to activate the glucagon-like peptide-1 receptor (GLP-1R) enhances glucose-dependent insulin secretion and improves energy balance in patients with type 2 diabetes mellitus. Studies investigating mechanisms whereby peptide ligands activate GLP-1R have utilized mutagenesis, r...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Bueno, Ana B., Showalter, Aaron D., Wainscott, David B., Stutsman, Cynthia, Marín, Aranzazu, Ficorilli, James, Cabrera, Over, Willard, Francis S., Sloop, Kyle W.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4865917/
https://ncbi.nlm.nih.gov/pubmed/26975372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.696039
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