Disconnect between signalling potency and in vivo efficacy of pharmacokinetically optimised biased glucagon-like peptide-1 receptor agonists

Por Lucey, Maria, Pickford, Philip, Bitsi, Stavroula, Minnion, James, Ungewiss, Jan, Schoeneberg, Katja, Rutter, Guy A., Bloom, Stephen R., Tomas, Alejandra, Jones, Ben
Publicado no Mol Metab (2020)

Randomized, Double-Blind Study of the Safety, Tolerability, and Efficacy of Tafenoquine versus Mefloquine for Malaria Prophylaxis in Nonimmune Subjects

Por Nasveld, Peter E., Edstein, Michael D., Reid, Mark, Brennan, Leonard, Harris, Ivor E., Kitchener, Scott J., Leggat, Peter A., Pickford, Philip, Kerr, Caron, Ohrt, Colin, Prescott, William
Publicado em 2010

Signalling, trafficking and glucoregulatory properties of glucagon‐like peptide‐1 receptor agonists exendin‐4 and lixisenatide

Por Pickford, Philip, Lucey, Maria, Fang, Zijian, Bitsi, Stavroula, de la Serna, Jorge Bernardino, Broichhagen, Johannes, Hodson, David J., Minnion, James, Rutter, Guy A., Bloom, Stephen R., Tomas, Alejandra, Jones, Ben
Publicado no Br J Pharmacol (2020)

The Influence of Peptide Context on Signaling and Trafficking of Glucagon-like Peptide-1 Receptor Biased Agonists

Por Fang, Zijian, Chen, Shiqian, Pickford, Philip, Broichhagen, Johannes, Hodson, David J., Corrêa, Ivan R., Kumar, Sunil, Görlitz, Frederik, Dunsby, Chris, French, Paul M. W., Rutter, Guy A., Tan, Tricia, Bloom, Stephen R., Tomas, Alejandra, Jones, Ben
Publicado no ACS Pharmacol Transl Sci (2020)