Genetic and biased agonist-mediated reductions in β-arrestin recruitment prolong cAMP signaling at glucagon family receptors

Receptors for the peptide hormones glucagon-like peptide-1 (GLP-1R), glucose-dependent insulinotropic polypeptide (GIPR), and glucagon (GCGR) are important regulators of insulin secretion and energy metabolism. GLP-1R agonists have been successfully deployed for the treatment of type 2 diabetes, but...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Jones, Ben, McGlone, Emma Rose, Fang, Zijian, Pickford, Phil, Corrêa, Ivan R., Oishi, Atsuro, Jockers, Ralf, Inoue, Asuka, Kumar, Sunil, Görlitz, Frederik, Dunsby, Chris, French, Paul M.W., Rutter, Guy A., Tan, Tricia, Tomas, Alejandra, Bloom, Stephen R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2020
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948418/
https://ncbi.nlm.nih.gov/pubmed/33268378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.016334
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