A unique mutator phenotype reveals complementary oncogenic lesions leading to acute leukemia

Mice homozygous for a hypomorphic allele of DNA replication factor minichromosome maintenance protein 2 (designated Mcm2(cre/cre)) develop precursor T cell lymphoblastic leukemia/lymphoma (pre-T LBL) with 4–32 small interstitial deletions per tumor. Mice that express a NUP98-HOXD13 (NHD13) transgene...

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Detalles Bibliográficos
Publicado en:JCI Insight
Main Authors: Yin, Mianmian, Baslan, Timour, Walker, Robert L., Zhu, Yuelin J., Freeland, Amy, Matsukawa, Toshihiro, Sridharan, Sriram, Nussenzweig, André, Pruitt, Steven C., Lowe, Scott W., Meltzer, Paul S., Aplan, Peter D.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6962024/
https://ncbi.nlm.nih.gov/pubmed/31622281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.131434
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