SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function

SUMMARY: Myelodysplastic syndrome (MDS), a largely incurable hematological malignancy, is derived from aberrant clonal hematopoietic stem/progenitor cells (HSPCs) that persist after conventional therapies. Defining mechanisms underlying MDS HSPC maintenance is critical for developing MDS therapy. Th...

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Detaylı Bibliyografya
Yayımlandı:Cell Stem Cell
Asıl Yazarlar: Sun, Jie, He, Xin, Zhu, Yinghui, Ding, Zonghui, Dong, Haojie, Feng, Yimei, Du, Juan, Wang, Hanying, Wu, Xiwei, Zhang, Lei, Yu, Xiaochun, Lin, Allen, McDonald, Tinisha, Zhao, Dandan, Wu, Herman, Hua, Wei-Kai, Zhang, Bin, Feng, Lifeng, Tohyama, Kaoru, Bhatia, Ravi, Oberdoerffer, Philipp, Chung, Yang Jo, Apian, Peter D., Boultwood, Jacqueline, Pellagatti, Andrea, Khaled, Samer, Kortylewski, Marcin, Pichiorri, Flavia, Kuo, Ya-Huei, Carlesso, Nadia, Marcucci, Guido, Jin, Hongchuan, Li, Ling
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6143172/
https://ncbi.nlm.nih.gov/pubmed/30146412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2018.07.018
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