HDAC4 inhibition disrupts TET2 function in high-risk MDS and AML

Aberrant DNA methylation often silences transcription of tumor-suppressor genes and is considered a hallmark of myeloid neoplasms. Similarly, histone deacetylation represses transcription of genes responsible for cell differentiation/death. A previous clinical study suggested potential pharmacodynam...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Huang, Feiteng, Sun, Jie, Chen, Wei, He, Xin, Zhu, Yinghui, Dong, Haojie, Wang, Hanying, Li, Zheng, Zhang, Lei, Khaled, Samer, Marcucci, Guido, Huang, Jinwen, Li, Ling
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7521497/
https://ncbi.nlm.nih.gov/pubmed/32726753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103605
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados