HDAC4 inhibition disrupts TET2 function in high-risk MDS and AML

Aberrant DNA methylation often silences transcription of tumor-suppressor genes and is considered a hallmark of myeloid neoplasms. Similarly, histone deacetylation represses transcription of genes responsible for cell differentiation/death. A previous clinical study suggested potential pharmacodynam...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Aging (Albany NY)
Prif Awduron: Huang, Feiteng, Sun, Jie, Chen, Wei, He, Xin, Zhu, Yinghui, Dong, Haojie, Wang, Hanying, Li, Zheng, Zhang, Lei, Khaled, Samer, Marcucci, Guido, Huang, Jinwen, Li, Ling
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals 2020
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7521497/
https://ncbi.nlm.nih.gov/pubmed/32726753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103605
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