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Aromatase Inhibitor-Mediated Down Regulation of INrf2 (Keap1) Leads to Increased Nrf2 and Resistance in Breast Cancer

Aromatase inhibitors (AIs) are effective drugs that reduce or eliminate hormone sensitive breast cancer. However, despite their efficacy, resistance to these drugs can occur in some patients. The INrf2 (Keap1):Nrf2 complex serves as a sensor of drug/radiation-induced oxidative/electrophilic stress....

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Khatri, Raju, Shah, Preeti, Guha, Rupa, Rassool, Feyruz V., Tomkinson, Alan E., Brodie, Angela, Jaiswal, Anil K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497835/
https://ncbi.nlm.nih.gov/pubmed/25976679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0672
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