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Aromatase Inhibitor-Mediated Down Regulation of INrf2 (Keap1) Leads to Increased Nrf2 and Resistance in Breast Cancer
Aromatase inhibitors (AIs) are effective drugs that reduce or eliminate hormone sensitive breast cancer. However, despite their efficacy, resistance to these drugs can occur in some patients. The INrf2 (Keap1):Nrf2 complex serves as a sensor of drug/radiation-induced oxidative/electrophilic stress....
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| Vydáno v: | Mol Cancer Ther |
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| Hlavní autoři: | , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4497835/ https://ncbi.nlm.nih.gov/pubmed/25976679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0672 |
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