Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction

The Rictor/mTOR complex (also known as mTORC2) plays a critical role in cellular homeostasis by phosphorylating AGC kinases such as Akt and SGK at their hydrophobic motifs to activate downstream signaling. However, the regulation of mTORC2 and whether it has additional function(s), remains largely u...

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Main Authors: Gao, Daming, Wan, Lixin, Inuzuka, Hiroyuki, Berg, Anders H., Tseng, Alan, Zhai, Bo, Shaik, Shavali, Bennett, Eric, Tron, Adriana E., Gasser, Jessica A., Lau, Alan, Gygi, Steven, Harper, J. Wade, DeCaprio, James A., Toker, Alex, Wei, Wenyi
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939073/
https://ncbi.nlm.nih.gov/pubmed/20832730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.08.016
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