Mcl-1 Ubiquitination and Destruction

Loss of the Fbw7 tumor suppressor is common in diverse human cancer types, including T-Cell Acute Lymphoblastic Leukemia (T-ALL), although the mechanistic basis of its anti-oncogenic activity remains largely unclear. We recently reported that SCF(Fbw7) regulates cellular apoptosis by controlling the...

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Dettagli Bibliografici
Autori principali: Inuzuka, Hiroyuki, Fukushima, Hidefumi, Shaik, Shavali, Liu, Pengda, Lau, Alan W., Wei, Wenyi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2011
Soggetti:
Research Perspectives
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3260810/
https://ncbi.nlm.nih.gov/pubmed/21608150
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