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Phosphorylation by Akt1 Promotes Skp2 Cytoplasmic Localization and Impairs APC/Cdh1-mediated Skp2 Destruction
Deregulated Skp2 function promotes cell transformation, and this is consistent with observations of Skp2 over-expression in many human cancers. However, the mechanisms underlying elevated Skp2 expression remain elusive. Here we report that the serine/threonine protein kinase Akt1, but not Akt2, dire...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2910589/ https://ncbi.nlm.nih.gov/pubmed/19270695 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1847 |
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