Φορτώνει......
Phosphorylation by Akt1 Promotes Skp2 Cytoplasmic Localization and Impairs APC/Cdh1-mediated Skp2 Destruction
Deregulated Skp2 function promotes cell transformation, and this is consistent with observations of Skp2 over-expression in many human cancers. However, the mechanisms underlying elevated Skp2 expression remain elusive. Here we report that the serine/threonine protein kinase Akt1, but not Akt2, dire...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , |
|---|---|
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2009
|
| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2910589/ https://ncbi.nlm.nih.gov/pubmed/19270695 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1847 |
| Ετικέτες: |
Προσθήκη ετικέτας
Δεν υπάρχουν, Καταχωρήστε ετικέτα πρώτοι!
|