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Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors
The PI3K–AKT kinase signaling pathway is frequently deregulated in human cancers, particularly breast cancer where amplification and somatic mutations of the PIK3CA gene occur with high frequency in patients. Numerous small molecule inhibitors targeting both PI3K and AKT are under clinical evaluatio...
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| Publié dans: | Sci Signal |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5902813/ https://ncbi.nlm.nih.gov/pubmed/29535262 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aao3810 |
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