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Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors
The PI3K–AKT kinase signaling pathway is frequently deregulated in human cancers, particularly breast cancer where amplification and somatic mutations of the PIK3CA gene occur with high frequency in patients. Numerous small molecule inhibitors targeting both PI3K and AKT are under clinical evaluatio...
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| Izdano u: | Sci Signal |
|---|---|
| Glavni autori: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5902813/ https://ncbi.nlm.nih.gov/pubmed/29535262 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aao3810 |
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