Acetylation-Dependent Regulation of Skp2 Function

Aberrant Skp2 signaling has been implicated as a driving event in tumorigenesis. Although the underlying molecular mechanisms remain elusive, cytoplasmic Skp2 correlates with more aggressive forms of breast and prostate cancers. Here, we report that Skp2 is acetylated by p300 at K68 and K71, which i...

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Detalhes bibliográficos
Main Authors: Inuzuka, Hiroyuki, Gao, Daming, Finley, Lydia W.S., Yang, Wen, Wan, Lixin, Fukushima, Hidefumi, Chin, Y. Rebecca, Zhai, Bo, Shaik, Shavali, Lau, Alan W., Wang, Zhiwei, Gygi, Steven P., Nakayama, Keiko, Teruya-Feldstein, Julie, Toker, Alex, Haigis, Marcia C., Pandolfi, Pier Paolo, Wei, Wenyi
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3595190/
https://ncbi.nlm.nih.gov/pubmed/22770219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.05.038
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