Acetylation-Dependent Regulation of Skp2 Function

Aberrant Skp2 signaling has been implicated as a driving event in tumorigenesis. Although the underlying molecular mechanisms remain elusive, cytoplasmic Skp2 correlates with more aggressive forms of breast and prostate cancers. Here, we report that Skp2 is acetylated by p300 at K68 and K71, which i...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Inuzuka, Hiroyuki, Gao, Daming, Finley, Lydia W.S., Yang, Wen, Wan, Lixin, Fukushima, Hidefumi, Chin, Y. Rebecca, Zhai, Bo, Shaik, Shavali, Lau, Alan W., Wang, Zhiwei, Gygi, Steven P., Nakayama, Keiko, Teruya-Feldstein, Julie, Toker, Alex, Haigis, Marcia C., Pandolfi, Pier Paolo, Wei, Wenyi
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2012
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3595190/
https://ncbi.nlm.nih.gov/pubmed/22770219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.05.038
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