Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction

The Rictor/mTOR complex (also known as mTORC2) plays a critical role in cellular homeostasis by phosphorylating AGC kinases such as Akt and SGK at their hydrophobic motifs to activate downstream signaling. However, the regulation of mTORC2 and whether it has additional function(s), remains largely u...

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Main Authors: Gao, Daming, Wan, Lixin, Inuzuka, Hiroyuki, Berg, Anders H., Tseng, Alan, Zhai, Bo, Shaik, Shavali, Bennett, Eric, Tron, Adriana E., Gasser, Jessica A., Lau, Alan, Gygi, Steven, Harper, J. Wade, DeCaprio, James A., Toker, Alex, Wei, Wenyi
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939073/
https://ncbi.nlm.nih.gov/pubmed/20832730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.08.016
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