Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction

The Rictor/mTOR complex (also known as mTORC2) plays a critical role in cellular homeostasis by phosphorylating AGC kinases such as Akt and SGK at their hydrophobic motifs to activate downstream signaling. However, the regulation of mTORC2 and whether it has additional function(s), remains largely u...

詳細記述

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書誌詳細
主要な著者: Gao, Daming, Wan, Lixin, Inuzuka, Hiroyuki, Berg, Anders H., Tseng, Alan, Zhai, Bo, Shaik, Shavali, Bennett, Eric, Tron, Adriana E., Gasser, Jessica A., Lau, Alan, Gygi, Steven, Harper, J. Wade, DeCaprio, James A., Toker, Alex, Wei, Wenyi
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939073/
https://ncbi.nlm.nih.gov/pubmed/20832730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.08.016
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