Negative Regulation of the Stability and Tumor Suppressor Function of Fbw7 by the Pin1 Prolyl Isomerase

Fbw7 is the substrate recognition component of the SCF (Skp1-Cullin-F-box)-type E3 ligase complex and a well-characterized tumor suppressor that targets numerous oncoproteins for destruction. Genomic deletion or mutation of FBW7 has been frequently found in various types of human cancers, however, l...

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Autors principals: Min, Sang-Hyun, Lau, Alan W., Lee, Tae Ho, Inuzuka, Hiroyuki, Wei, Shuo, Huang, Pengyu, Shaik, Shavali, Lee, Daniel Yenhong, Finn, Greg, Balastik, Martin, Chen, Chun-Hau, Luo, Manli, Tron, Adriana E., DeCaprio, James A., Zhou, Xiao Zhen, Wei, Wenyi, Lu, Kun Ping
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3389221/
https://ncbi.nlm.nih.gov/pubmed/22608923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.04.012
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