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Orally Bioavailable Potent Soluble Epoxide Hydrolase Inhibitors

A series of N,N′-disubstituted ureas having a conformationally restricted cis- or trans-1,4-cyclohexane α to the urea were prepared and tested as soluble epoxide hydrolase (sEH) inhibitors. This series of compounds showed low nanomolar to picomolar activities against recombinant human sEH. Both isom...

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Detalhes bibliográficos
Main Authors: Hwang, Sung Hee, Tsai, Hsing-Ju, Liu, Jun-Yan, Morisseau, Christophe, Hammock, Bruce D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596069/
https://ncbi.nlm.nih.gov/pubmed/17616115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm070270t
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