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Peptidyl-urea based inhibitors of soluble epoxide hydrolases
We prepared a series of amino acid derived cyclohexyl and adamantyl ureas and tested them as inhibitors of the human soluble epoxide hydrolase, and obtained very potent compounds (K(I) = 15 nM) that are >10-fold more soluble than previously described sEH inhibitors. While our lead compound 2 show...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1892215/ https://ncbi.nlm.nih.gov/pubmed/16908134 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2006.07.073 |
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