In vitro and in vivo metabolism of N-adamantyl substituted urea-based soluble epoxide hydrolase inhibitors

N,N′-Disubstituted urea-based soluble epoxide hydrolase (sEH) inhibitors are promising therapeutics for hypertension, inflammation, and pain in multiple animal models. The drug absorption and pharmacological efficacy of these inhibitors have been reported extensively. However, the drug metabolism of...

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Bibliografische gegevens
Gepubliceerd in:Biochem Pharmacol
Hoofdauteurs: Liu, Jun-Yan, Tsai, Hsing-Ju, Morisseau, Christophe, Lango, Jozsef, Hwang, Sung Hee, Watanabe, Takaho, Kim, In-Hae, Hammock, Bruce D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4656071/
https://ncbi.nlm.nih.gov/pubmed/26494425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2015.10.013
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