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Adamantyl thioureas as soluble epoxide hydrolase inhibitors
A series of inhibitors of the soluble epoxide hydrolase (sEH) containing one or two thiourea groups has been developed. Inhibition potency of the described compounds ranges from 50 μM to 7.2 nM. 1,7-(Heptamethylene)bis[(adamant-1-yl)thiourea] (6f) was found to be the most potent sEH inhibitor, among...
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| Publicat a: | Bioorg Med Chem Lett |
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| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6442743/ https://ncbi.nlm.nih.gov/pubmed/29803731 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.05.024 |
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