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Adamantyl thioureas as soluble epoxide hydrolase inhibitors

A series of inhibitors of the soluble epoxide hydrolase (sEH) containing one or two thiourea groups has been developed. Inhibition potency of the described compounds ranges from 50 μM to 7.2 nM. 1,7-(Heptamethylene)bis[(adamant-1-yl)thiourea] (6f) was found to be the most potent sEH inhibitor, among...

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Bibliografiske detaljer
Udgivet i:Bioorg Med Chem Lett
Main Authors: Burmistrov, Vladimir, Morisseau, Christophe, Pitushkin, Dmitry, Karlov, Dmitry, Fayzullin, Robert R., Butov, Gennady M., Hammock, Bruce D.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442743/
https://ncbi.nlm.nih.gov/pubmed/29803731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.05.024
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