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Effects of adamantane alterations on soluble epoxide hydrolase inhibition potency, physical properties and metabolic stability
Adamantyl groups are widely used in medicinal chemistry. However, metabolism limits their usage. Herein, we report the first systematic study of adamantyl ureas and diureas bearing substituents in bridgehead positions of adamantane and/or spacers between urea groups and adamantane group, and tested...
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| Publicado no: | Bioorg Chem |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5837815/ https://ncbi.nlm.nih.gov/pubmed/29310082 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2017.12.024 |
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