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Effects of adamantane alterations on soluble epoxide hydrolase inhibition potency, physical properties and metabolic stability

Adamantyl groups are widely used in medicinal chemistry. However, metabolism limits their usage. Herein, we report the first systematic study of adamantyl ureas and diureas bearing substituents in bridgehead positions of adamantane and/or spacers between urea groups and adamantane group, and tested...

詳細記述

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書誌詳細
出版年:Bioorg Chem
主要な著者: Burmistrov, Vladimir, Morisseau, Christophe, Harris, Todd R., Butov, Gennady, Hammock, Bruce D.
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837815/
https://ncbi.nlm.nih.gov/pubmed/29310082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2017.12.024
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