Imidazolidine-2,4,5- and pirimidine-2,4,6-triones – new primary pharmacophore for soluble epoxide hydrolase inhibitors with enhanced water solubility.

A series of inhibitors of the soluble epoxide hydrolase (sEH) containing imidazolidine-2,4,5-trione or pirimidine-2,4,6-trione has been synthesized. Inhibition potency of the described compounds ranges from 8.4 μM to 0.4 nM. The tested compounds possess higher water solubility than their preceding u...

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Veröffentlicht in:Bioorg Med Chem Lett
Hauptverfasser: Burmistrov, Vladimir, Morisseau, Christophe, D’yachenko, Vladimir, Karlov, Dmitry, Butov, Gennady M., Hammock, Bruce D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6957307/
https://ncbi.nlm.nih.gov/pubmed/31870649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.126908
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