Fluoroaromatic fragments on 1,3-disubstituted ureas enhance soluble epoxide hydrolase inhibition

A series of soluble epoxide hydrolase (sEH) inhibitors containing 2-fluorophenyl fragment was developed. Inhibition potency of the described compounds ranges from 0.7 to 630.9 nM. 1-(Adamantan-1-ylmethyl)-3-(2-fluorophenyl) urea (3b, IC(50) = 0.7 nM) and 1-(adamantan-2-yl)-3-(2-fluorophenyl) urea (3...

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Pubblicato in:J Fluor Chem
Autori principali: Burmistrov, Vladimir, Morisseau, Christophe, D’yachenko, Vladimir, Rybakov, Victor B., Butov, Gennady M., Hammock, Bruce D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7055688/
https://ncbi.nlm.nih.gov/pubmed/32132741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jfluchem.2019.02.005
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