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Fluoroaromatic fragments on 1,3-disubstituted ureas enhance soluble epoxide hydrolase inhibition
A series of soluble epoxide hydrolase (sEH) inhibitors containing 2-fluorophenyl fragment was developed. Inhibition potency of the described compounds ranges from 0.7 to 630.9 nM. 1-(Adamantan-1-ylmethyl)-3-(2-fluorophenyl) urea (3b, IC(50) = 0.7 nM) and 1-(adamantan-2-yl)-3-(2-fluorophenyl) urea (3...
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| Publicat a: | J Fluor Chem |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7055688/ https://ncbi.nlm.nih.gov/pubmed/32132741 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jfluchem.2019.02.005 |
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