1,3-Disubstituted and 1,3,3-trisubstituted adamantyl-ureas with isoxazole as soluble epoxide hydrolase inhibitors

Adamantyl ureas are good soluble epoxide hydrolase (sEH) inhibitors; however they have limited solubility and rapid metabolism, thus limiting their usefulness in some therapeutic indications. Herein, we test the hypothesis that nodal substitution on the adamantane will help solubilize and stabilize...

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Bibliografske podrobnosti
izdano v:Bioorg Med Chem Lett
Main Authors: Burmistrov, Vladimir, Morisseau, Christophe, Danilov, Dmitry, Harris, Todd R., Dalinger, Igor, Vatsadze, Irina, Shkineva, Tatiana, Butov, Gennady M., Hammock, Bruce D.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4654407/
https://ncbi.nlm.nih.gov/pubmed/26520661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.10.066
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