1,3-Disubstituted and 1,3,3-trisubstituted adamantyl-ureas with isoxazole as soluble epoxide hydrolase inhibitors

Adamantyl ureas are good soluble epoxide hydrolase (sEH) inhibitors; however they have limited solubility and rapid metabolism, thus limiting their usefulness in some therapeutic indications. Herein, we test the hypothesis that nodal substitution on the adamantane will help solubilize and stabilize...

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Publicat a:Bioorg Med Chem Lett
Autors principals: Burmistrov, Vladimir, Morisseau, Christophe, Danilov, Dmitry, Harris, Todd R., Dalinger, Igor, Vatsadze, Irina, Shkineva, Tatiana, Butov, Gennady M., Hammock, Bruce D.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4654407/
https://ncbi.nlm.nih.gov/pubmed/26520661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.10.066
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