In vitro and in vivo metabolism of N-adamantyl substituted urea-based soluble epoxide hydrolase inhibitors

N,N′-Disubstituted urea-based soluble epoxide hydrolase (sEH) inhibitors are promising therapeutics for hypertension, inflammation, and pain in multiple animal models. The drug absorption and pharmacological efficacy of these inhibitors have been reported extensively. However, the drug metabolism of...

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Detalhes bibliográficos
Publicado no:Biochem Pharmacol
Main Authors: Liu, Jun-Yan, Tsai, Hsing-Ju, Morisseau, Christophe, Lango, Jozsef, Hwang, Sung Hee, Watanabe, Takaho, Kim, In-Hae, Hammock, Bruce D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4656071/
https://ncbi.nlm.nih.gov/pubmed/26494425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2015.10.013
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