Yüklüyor......
Synthesis and SAR of conformationally restricted inhibitors of soluble epoxide hydrolase
A series of conformationally restricted inhibitors of human soluble epoxide hydrolase (sEH) has been developed. Inhibition potency of the described compounds ranges from 4.2 μM to 1.1 nM against recombinant sEH. N-(1-Acetylpiperidin-4-yl)-N′-(adamant-1-yl) urea (5a) was found to be a potent inhibito...
Kaydedildi:
| Asıl Yazarlar: | , , , , |
|---|---|
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2006
|
| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1904344/ https://ncbi.nlm.nih.gov/pubmed/16870439 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2006.07.009 |
| Etiketler: |
Etiketle
Etiket eklenmemiş, İlk siz ekleyin!
|