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Synthesis and SAR of conformationally restricted inhibitors of soluble epoxide hydrolase
A series of conformationally restricted inhibitors of human soluble epoxide hydrolase (sEH) has been developed. Inhibition potency of the described compounds ranges from 4.2 μM to 1.1 nM against recombinant sEH. N-(1-Acetylpiperidin-4-yl)-N′-(adamant-1-yl) urea (5a) was found to be a potent inhibito...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1904344/ https://ncbi.nlm.nih.gov/pubmed/16870439 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2006.07.009 |
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