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Solid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors
A 192-member library of N,N′-disubstituted urea inhibitors was synthesized by a solid-phase method. The ureas were tested for their inhibitory activities against recombinant human soluble epoxide hydrolase. Simple carbocyclic or para/meta-substituted phenyl groups showed inhibition potencies that we...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1904340/ https://ncbi.nlm.nih.gov/pubmed/16949285 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2006.08.078 |
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