Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase

Multi-target inhibitors have become increasing popular as a means to leverage the advantages of poly-pharmacology while simplifying drug delivery. Here, we describe dual inhibitors for soluble epoxide hydrolase (sEH) and fatty acid amide hydrolase (FAAH), two targets known to synergize when treating...

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Detaylı Bibliyografya
Yayımlandı:Bioorg Med Chem Lett
Asıl Yazarlar: Kodani, Sean D., Bhakta, Saavan, Hwang, Sung Hee, Pakhomova, Svetlana, Newcomer, Marcia E., Morisseau, Christophe, Hammock, Bruce D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837813/
https://ncbi.nlm.nih.gov/pubmed/29366648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.01.003
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