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Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides

The soluble epoxide hydrolase (sEH) is a key enzyme in the metabolism of epoxy-fatty acids, signaling molecules involved in numerous biologies. Toward finding novel inhibitors of sEH, a library of known drugs was tested for inhibition of sEH. We found that fulvestrant, an anticancer agent, is a pote...

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Библиографические подробности
Главные авторы: Morisseau, Christophe, Pakhomova, Svitlana, Hwang, Sung Hee, Newcomer, Marcia E, Hammock, Bruce D.
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703951/
https://ncbi.nlm.nih.gov/pubmed/23684894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.04.083
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