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Identification of potent inhibitors of the chicken soluble epoxide hydrolase

In vertebrates, soluble epoxide hydrolase (sEH) hydrolyzes natural epoxy-fatty acids (EpFAs), which are chemical mediators modulating inflammation, pain, and angiogenesis. Chick embryos are used to study angiogenesis, particularly its role in cardiovascular biology and pathology. To find potent and...

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Detalles Bibliográficos
Publicado en:Bioorg Med Chem Lett
Autores principales: Shihadih, Diyala S., Harris, Todd R., Yang, Jun, Merzlikin, Oleg, Lee, Kin Sing S., Hammock, Bruce D., Morisseau, Christophe
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4277729/
https://ncbi.nlm.nih.gov/pubmed/25479771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.11.053
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