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Identification of potent inhibitors of the chicken soluble epoxide hydrolase

In vertebrates, soluble epoxide hydrolase (sEH) hydrolyzes natural epoxy-fatty acids (EpFAs), which are chemical mediators modulating inflammation, pain, and angiogenesis. Chick embryos are used to study angiogenesis, particularly its role in cardiovascular biology and pathology. To find potent and...

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Détails bibliographiques
Publié dans:Bioorg Med Chem Lett
Auteurs principaux: Shihadih, Diyala S., Harris, Todd R., Yang, Jun, Merzlikin, Oleg, Lee, Kin Sing S., Hammock, Bruce D., Morisseau, Christophe
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4277729/
https://ncbi.nlm.nih.gov/pubmed/25479771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.11.053
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