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Biologically Active Ester Derivatives as Potent Inhibitors of the Soluble Epoxide Hydrolase

Substituted ureas with a carboxylic acid ester as a secondary pharmacophore are potent soluble epoxide hydrolase (sEH) inhibitors. Although the ester substituent imparts better physical properties, such compounds are quickly metabolized to the corresponding less potent acids. Toward producing biolog...

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Detalhes bibliográficos
Main Authors: Kim, In-Hae, Nishi, Kosuke, Kasagami, Takeo, Morisseau, Christophe, Liu, Jun-Yan, Tsai, Hsing-Ju, Hammock, Bruce D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3432147/
https://ncbi.nlm.nih.gov/pubmed/22901393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.07.074
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