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Biologically Active Ester Derivatives as Potent Inhibitors of the Soluble Epoxide Hydrolase

Substituted ureas with a carboxylic acid ester as a secondary pharmacophore are potent soluble epoxide hydrolase (sEH) inhibitors. Although the ester substituent imparts better physical properties, such compounds are quickly metabolized to the corresponding less potent acids. Toward producing biolog...

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Bibliografiske detaljer
Main Authors: Kim, In-Hae, Nishi, Kosuke, Kasagami, Takeo, Morisseau, Christophe, Liu, Jun-Yan, Tsai, Hsing-Ju, Hammock, Bruce D.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3432147/
https://ncbi.nlm.nih.gov/pubmed/22901393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.07.074
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