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Orally Bioavailable Potent Soluble Epoxide Hydrolase Inhibitors
A series of N,N′-disubstituted ureas having a conformationally restricted cis- or trans-1,4-cyclohexane α to the urea were prepared and tested as soluble epoxide hydrolase (sEH) inhibitors. This series of compounds showed low nanomolar to picomolar activities against recombinant human sEH. Both isom...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2007
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2596069/ https://ncbi.nlm.nih.gov/pubmed/17616115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm070270t |
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