Identification of the endosomal sorting complex required for transport-I (ESCRT-I) as an important modulator of anti-miR uptake by cancer cells

Mechanisms of unassisted delivery of RNA therapeutics, including inhibitors of microRNAs, remain poorly understood. We observed that the hepatocellular carcinoma cell line SKHEP1 retains productive free uptake of a miR-21 inhibitor (anti-miR-21). Uptake of anti-miR-21, but not a mismatch (MM) contro...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Wagenaar, Timothy R., Tolstykh, Tatiana, Shi, Chaomei, Jiang, Lan, Zhang, JingXin, Li, Zhifang, Yu, Qunyan, Qu, Hui, Sun, Fangxian, Cao, Hui, Pollard, Jack, Dai, Shujia, Gao, Qiang, Zhang, Bailin, Arlt, Heike, Cindhuchao, May, Hoffmann, Dietmar, Light, Madelyn, Jensen, Karin, Hopke, Joern, Newcombe, Richard, Garcia-Echeverria, Carlos, Winter, Christopher, Zabludoff, Sonya, Wiederschain, Dmitri
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333411/
https://ncbi.nlm.nih.gov/pubmed/25550434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1367
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