NVP‐TAE684 reverses multidrug resistance (MDR) in human osteosarcoma by inhibiting P‐glycoprotein (PGP1) function

BACKGROUND AND PURPOSE: Increased expression of P‐glycoprotein (PGP1) is one of the major causes of multidrug resistance (MDR) in cancer, including in osteosarcoma, which eventually leads to the failure of cancer chemotherapy. Thus, there is an urgent need to develop effective therapeutic strategies...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Ye, Shunan, Zhang, Jianming, Shen, Jacson, Gao, Yan, Li, Ying, Choy, Edwin, Cote, Gregory, Harmon, David, Mankin, Henry, Gray, Nathanael S, Hornicek, Francis J, Duan, Zhenfeng
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4728419/
https://ncbi.nlm.nih.gov/pubmed/26603906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13395
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