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p53 overexpression increases chemosensitivity in multidrug resistant osteosarcoma cell lines
PURPOSE: Multidrug resistance (MDR) is a major obstacle to the successful treatment of osteosarcoma with chemotherapy. Effectiveness of cancer therapy correlates with the ability to induce a p53-dependent apoptotic response. p53 is a tumor suppressor gene that is mutated in 22% of osteosarcomas. Whi...
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| Publié dans: | Cancer Chemother Pharmacol |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4749432/ https://ncbi.nlm.nih.gov/pubmed/26698867 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-015-2944-z |
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