NVP‐TAE684 reverses multidrug resistance (MDR) in human osteosarcoma by inhibiting P‐glycoprotein (PGP1) function

BACKGROUND AND PURPOSE: Increased expression of P‐glycoprotein (PGP1) is one of the major causes of multidrug resistance (MDR) in cancer, including in osteosarcoma, which eventually leads to the failure of cancer chemotherapy. Thus, there is an urgent need to develop effective therapeutic strategies...

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Detalles Bibliográficos
Publicado en:Br J Pharmacol
Autores principales: Ye, Shunan, Zhang, Jianming, Shen, Jacson, Gao, Yan, Li, Ying, Choy, Edwin, Cote, Gregory, Harmon, David, Mankin, Henry, Gray, Nathanael S, Hornicek, Francis J, Duan, Zhenfeng
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4728419/
https://ncbi.nlm.nih.gov/pubmed/26603906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13395
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