ERK1/2 BLOCKADE PREVENTS EPITHELIAL-MESENCHYMAL TRANSITION IN LUNG CANCER CELLS AND PROMOTES THEIR SENSITIVITY TO EGFR INHIBITION

von Buonato, Janine M., Lazzara, Matthew J.
Veröffentlicht 2013

Computational Analysis of the Regulation of EGFR by Protein Tyrosine Phosphatases

von Monast, Calixte S., Furcht, Christopher M., Lazzara, Matthew J.
Veröffentlicht 2012

Cell Signaling Regulation by Protein Phosphorylation: A Multivariate, Heterogeneous, and Context-dependent Process

von Day, Evan K., Sosale, Nisha G., Lazzara, Matthew J.
Veröffentlicht in Curr Opin Biotechnol (2016)

Diminished Functional Role and Altered Localization of Shp2 in Non-Small Cell Lung Cancer Cells With Egfr-Activating Mutations

von Furcht, Christopher M., Rojas, Andres Muñoz, Nihalani, Deepak, Lazzara, Matthew J.
Veröffentlicht 2012

Glioblastoma Cell Resistance to EGFR and MET Inhibition Can Be Overcome via Blockade of FGFR-SPRY2 Bypass Signaling

von Day, Evan K., Sosale, Nisha G., Xiao, Aizhen, Zhong, Qing, Purow, Benjamin, Lazzara, Matthew J.
Veröffentlicht in Cell Rep (2020)

Localization dynamics of endogenous fluorescently labeled RAF1 in EGF-stimulated cells

von Surve, Sachin V., Myers, Paul J., Clayton, Samantha A., Watkins, Simon C., Lazzara, Matthew J., Sorkin, Alexander
Veröffentlicht in Mol Biol Cell (2019)

Disrupting the transmembrane domain–mediated oligomerization of protein tyrosine phosphatase receptor J inhibits EGFR-driven cancer cell phenotypes

von Bloch, Elizabeth, Sikorski, Eden L., Pontoriero, David, Day, Evan K., Berger, Bryan W., Lazzara, Matthew J., Thévenin, Damien
Veröffentlicht in J Biol Chem (2019)

ERK-dependent suicide gene therapy for selective targeting of RTK/RAS-driven cancers

von Day, Evan K., Campbell, Anne, Pandolf, Ashley, Rogerson, Troy, Zhong, Qing, Xiao, Aizhen, Purow, Benjamin, Lazzara, Matthew J.
Veröffentlicht in Mol Ther (2021)

Multivariate signaling regulation by SHP2 differentially controls proliferation and therapeutic response in glioma cells

von Furcht, Christopher M., Buonato, Janine M., Skuli, Nicolas, Mathew, Lijoy K., Muñoz Rojas, Andrés R., Simon, M. Celeste, Lazzara, Matthew J.
Veröffentlicht 2014

IMPAIRED SHP2-MEDIATED ERK ACTIVATION CONTRIBUTES TO GEFITINIB SENSITIVITY OF LUNG CANCER CELLS WITH EGFR-ACTIVATING MUTATIONS

von Lazzara, Matthew J., Lane, Keara, Chan, Richard, Jasper, Paul J., Yaffe, Michael B., Sorger, Peter K., Jacks, Tyler, Neel, Benjamin G., Lauffenburger, Douglas A.
Veröffentlicht 2010

An engineering design approach to systems biology

von Janes, Kevin A., Chandran, Preethi L., Ford, Roseanne M., Lazzara, Matthew J., Papin, Jason A., Peirce, Shayn M., Saucerman, Jeffrey J., Lauffenburger, Douglas A.
Veröffentlicht in Integr Biol (Camb) (2017)

Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complex

von D'Souza, Ryan S, Lim, Jun Y, Turgut, Alper, Servage, Kelly, Zhang, Junmei, Orth, Kim, Sosale, Nisha G, Lazzara, Matthew J, Allegood, Jeremy, Casanova, James E
Veröffentlicht in eLife (2020)

Mathematical Model Predicts that Acceleration of Diabetic Wound Healing is Dependent on Spatial Distribution of VEGF-A mRNA (AZD8601)

von Rikard, S. Michaela, Myers, Paul J., Almquist, Joachim, Gennemark, Peter, Bruce, Anthony C., Wågberg, Maria, Fritsche-Danielson, Regina, Hansson, Kenny M., Lazzara, Matthew J., Peirce, Shayn M.
Veröffentlicht in Cell Mol Bioeng (2021)

SPROUTY2 DRIVES DRUG RESISTANCE AND PROLIFERATION IN GLIOBLASTOMA

von Walsh, Alice M., Kapoor, Gurpreet S., Buonato, Janine M., Mathew, Lijoy K., Bi, Yingtao, Davuluri, Ramana V., Martinez-Lage, Maria, Simon, M. Celeste, O’Rourke, Donald M., Lazzara, Matthew J.
Veröffentlicht in Mol Cancer Res (2015)

Effects of Proximal Tubule Shortening on Protein Excretion in a Lowe Syndrome Model

von Gliozzi, Megan L., Espiritu, Eugenel B., Shipman, Katherine E., Rbaibi, Youssef, Long, Kimberly R., Roy, Nairita, Duncan, Andrew W., Lazzara, Matthew J., Hukriede, Neil A., Baty, Catherine J., Weisz, Ora A.
Veröffentlicht in J Am Soc Nephrol (2020)

p53Ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state

von Senturk, Serif, Yao, Zhan, Camiolo, Matthew, Stiles, Brendon, Rathod, Trushar, Walsh, Alice M., Nemajerova, Alice, Lazzara, Matthew J., Altorki, Nasser K., Krainer, Adrian, Moll, Ute M., Lowe, Scott W., Cartegni, Luca, Sordella, Raffaella
Veröffentlicht 2014

Exocyst Sec10 protects renal tubule cells from injury by EGFR/MAPK activation and effects on endocytosis

von Fogelgren, Ben, Zuo, Xiaofeng, Buonato, Janine M., Vasilyev, Aleksandr, Baek, Jeong-In, Choi, Soo Young, Chacon-Heszele, Maria F., Palmyre, Aurélien, Polgar, Noemi, Drummond, Iain, Park, Kwon Moo, Lazzara, Matthew J., Lipschutz, Joshua H.
Veröffentlicht in Am J Physiol Renal Physiol (2014)

Reactivation of ERK Signaling causes resistance to EGFR kinase inhibitors

von Ercan, Dalia, Xu, Chunxiao, Yanagita, Masahiko, Monast, Calixte S., Pratilas, Christine A., Montero, Joan, Butaney, Mohit, Shimamura, Takeshi, Sholl, Lynette, Ivanova, Elena V., Tadi, Madhavi, Rogers, Andrew, Repellin, Claire, Capelletti, Marzia, Maertens, Ophélia, Goetz, Eva M., Letai, Anthony, Garraway, Levi A., Lazzara, Matthew J., Rosen, Neal, Gray, Nathanael S., Wong, Kwok-Kin, Jänne, Pasi A.
Veröffentlicht 2012